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SML0363 Sigma-Aldrich

DIM-C-pPhtBu

≥96% (HPLC)

Synonym: 1,1-Bis(3-indolyl)-1-(p-t-butylphenyl)methane, 3,3′-[[4-(1,1-Dimethylethyl)phenyl]methylene]bis-1H-indole

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Properties

Related Categories Antioxidants and Cytoprotectants, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ≥96% (HPLC)
form   powder
storage condition   desiccated
color   light orange to dark orange
solubility   DMSO: >15 mg/mL
storage temp.   −20°C
SMILES string   CC(C)(C)c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45
InChI   1S/C27H26N2/c1-27(2,3)19-14-12-18(13-15-19)26(22-16-28-24-10-6-4-8-20(22)24)23-17-29-25-11-7-5-9-21(23)25/h4-17,26,28-29H,1-3H3
InChI key   NCPVEZRBHNDCIV-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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