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SML0377 Sigma-Aldrich

(S)-FTY720 phosphate

≥94% (HPLC)

Synonym: (+)-(S)-FTY 720 phosphate, (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol), (S)-FTY 720P

  • CAS Number 402616-26-6

  • Empirical Formula (Hill Notation) C19H34NO5P

  • Molecular Weight 387.45

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F,
assay   ≥94% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: 0.3 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Biochem/physiol Actions

FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1PR) receptor agonist and immunomodulatory agent, the active metabolite of FTY720. FTY720P acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors and Lysophospholipid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Lysophospholipid Receptors

Although historically considered as intermediates in the biosynthesis of glycerophospholipids and the degradation of sphingolipids, the lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1...
Keywords: Atomic absorption spectroscopy, Cancer, Chemical biology, Degradations, Gene expression, Genetic, Genetics, Ligands, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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