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SML0397 Sigma-Aldrich

DR2313

≥98% (HPLC)

Synonym: 3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one

  • CAS Number 284028-90-6

  • Empirical Formula (Hill Notation) C8H10N2OS

  • Molecular Weight 182.24

  •  MDL number MFCD08703132

  •  PubChem Substance ID 329825393

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: >2 mg/mL (warmed)
storage temp.   2-8°C
SMILES string   CC1=NC(=O)C2=C(CCSC2)N1
InChI   1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChI key   HRYKZAKEAVZGJD-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DR2313 is a PARP-1; PARP-2 inhibitor (Ki = 0.23 mM). DR2313 has neuroprotective effects in both in vivo and in vitro ischemic models, and reduces cortical infarct volume in focal ischemia in rats.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Caspases

Caspases (Cysteine dependant Aspartate Specific Proteases) form a family of closely related enzymes (family C14; clan CD) involved in regulating a type of cell death known as apoptosis, inflammatory ...
Keywords: Alkylations, Alzheimer Disease, Apoptosis, Cancer, Catalysis, Clinical, Diseases, Gene expression, Huntington Disease, Inflammation, Ligands, Oncology, Parkinson Disease, Polymorphisms

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