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SML0434 Sigma-Aldrich

Gue1654

≥98% (HPLC)

Synonym: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole

  • CAS Number 397290-30-1

  • Empirical Formula (Hill Notation) C23H17N3OS3

  • Molecular Weight 447.60

  •  MDL number MFCD04419018

  •  PubChem Substance ID 329824717

  •  NACRES NA.77

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Properties

Related Categories Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution; warmed)
storage temp.   2-8°C
SMILES string   CSc1nc2ccc3nc(NC(=O)C(c4ccccc4)c5ccccc5)sc3c2s1
InChI   1S/C23H17N3OS3/c1-28-23-25-17-13-12-16-19(20(17)30-23)29-22(24-16)26-21(27)18(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-13,18H,1H3,(H,24,26,27)
InChI key   UFOBDFMYJABXGK-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Gue1654 inhibits signaling of the chemoattractant GPCR 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R), but only signaling involving Gβγ, not Gα signaling triggered upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 is the first small-molecule inhibitor for the oxoeicosanoid receptor and the first to uncouple Gα and Gβγ signaling within a heterotrimer for any GPCR.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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