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SML0439 Sigma-Aldrich

MBCQ

≥98% (HPLC)

Synonym: 4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline

  • CAS Number 150450-53-6

  • Empirical Formula (Hill Notation) C16H12ClN3O2

  • Molecular Weight 313.74

  •  MDL number MFCD00673946

  •  PubChem Substance ID 329824721

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution)
storage temp.   2-8°C
SMILES string   Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
InChI   1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
InChI key   CNODHOSDWZLJGA-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. They function with adenylyl and guanylyl cyclases to regulate the amplitude and duration of responses triggere...
Keywords: Amplification, Atomic absorption spectroscopy, Catalysis, Diabetes, Gene expression, Genetic, Hormones, Inflammation, Neurotransmitters, Obesity, Parkinson Disease, Phosphorylations, Physiological Processes, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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