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SML0441 Sigma-Aldrich

LUF6283

≥95% (HPLC)

Synonym: 5-Butyl-1H-Pyrazole-3-carboxylic acid

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism,
InChI Key   ZJTXSGLJNBAMJS-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL (clear solution; warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LUF6283 is a partial agonist of the hydroxy-carboxylic acid receptor 2 (HCA2; GPR109A). LUF6283 binds HCA2 with a Ki value of 0.55 mM, and an intrinsic efficacy for agonist activity of 76% of the full agonist effect of niacin. The EC50 values for niacin and LUF6283 are 0.41 and 3.1 mM, respectively. LUF6283 effectively lowers plasma lipid levels, but does not induce cutaneous flushing as observed with niacin treatment.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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