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SML0454 Sigma-Aldrich

SM-7368

≥98% (HPLC)

Synonym: 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM 7368

  • CAS Number 380623-76-7

  • Empirical Formula (Hill Notation) C10H5ClN4O5S

  • Molecular Weight 328.69

  •  MDL number MFCD00834007

  •  PubChem Substance ID 329824733

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL (clear solution)
storage temp.   2-8°C
SMILES string   [O-][N+](=O)c1cnc(NC(=O)c2ccc(c(Cl)c2)[N+]([O-])=O)s1
InChI   1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16)
InChI key   XCHLNGBTHLJLFG-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SM-7368 is a cell-permeable inhibitor of TNF-α-induced MMP-9 upregulation. Also, SM-7368 strongly inhibits TNF-α-induced NF-kB activity but not AP-1 activity. The compound inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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