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SML0456 Sigma-Aldrich

HBB2

≥98% (HPLC)

Synonym: (1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one

  • CAS Number 131359-24-5

  • Empirical Formula (Hill Notation) C17H14O3

  • Molecular Weight 266.29

  •  MDL number MFCD01790784

  •  PubChem Substance ID 329824735

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 15 mg/mL (clear solution)
storage temp.   −20°C
SMILES string   Oc1ccccc1\C=C\C(=O)\C=C\c2ccccc2O
InChI   1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+
InChI key   YNVAHBUBGBLIEY-WGDLNXRISA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

HBB2 is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. Also, HBB2 upregulates Hsp70 in an HSF1-dependent manner. It appears that HBB2 reacts with cysteine residues of KEAP1, which leads to activation of NRF2, and binds to Hsp90 Cys that leads to activation of HST1.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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