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SML0464 Sigma-Aldrich

SPA0355

≥98% (HPLC)

Synonym: N-Methyl-N′-[4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl]-thiourea

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
InChI Key   IEFRKIYTMPORCY-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white, to tan to gray
solubility   DMSO: 15 mg/mL (clear solution)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. In vivo, SPA0355 inhibits paw edema and joint destruction in a mouse collagen induced arthritis model.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Cytokine Receptors (Interleukin-1 Receptor/TIR Family)

The interleukin-1/TIR family in animals comprises three subgroups of proteins; of these, two are type I integral membrane receptor proteins and the third is a group of intracellular proteins. All fam...
Keywords: Gene expression, Hormones, Inflammation, Ligands, Transduction

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