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SML0468 Sigma-Aldrich

Dorzolamide

≥98% (HPLC)

Synonym: (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507

  • CAS Number 120279-96-1

  • Empirical Formula (Hill Notation) C10H16N2O4S3

  • Molecular Weight 324.44

  •  MDL number MFCD00865636

  •  PubChem Substance ID 329824746

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -25 to -35°, c = 1 in methanol
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution, warmed)
storage temp.   room temp
SMILES string   CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI   1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChI key   IAVUPMFITXYVAF-XPUUQOCRSA-N
Gene Information   human ... CA2(760)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
XJ9095169
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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