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SML0474 Sigma-Aldrich

(S)-Duloxetine hydrochloride

≥98% (HPLC)

Synonym: (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride

  • CAS Number 136434-34-9

  • Empirical Formula (Hill Notation) C18H19NOS · HCl

  • Molecular Weight 333.88

  •  MDL number MFCD06407958

  •  PubChem Substance ID 329825429

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biogenic Amine Transport Inhibitors, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +116 to +125°, c = 1 in methanol
color   white to beige
solubility   H2O: 5 mg/mL (clear solution, warmed)
storage temp.   room temp
SMILES string   Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI   1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI key   BFFSMCNJSOPUAY-LMOVPXPDSA-N
Gene Information   human ... SLC6A2(6530), SLC6A4(6532)

Description

General description

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

Application

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

air sensitive

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
XN0258000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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