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SML0483 Sigma-Aldrich

DpC

≥98% (HPLC)

Synonym: Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone

  • CAS Number 1382469-39-7

  • Empirical Formula (Hill Notation) C19H23N5S

  • Molecular Weight 353.48

  •  MDL number MFCD22666593

  •  PubChem Substance ID 329825434

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution)
storage temp.   −20°C
SMILES string   CN(C1CCCCC1)C(=S)N\N=C(\c2ccccn2)c3ccccn3
InChI   1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)
InChI key   GNLZNQJBZNOUBM-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DpC is an iron-chelating agent. In four separate human pancreatic tumor cell lines, DpC significantly increased the expression and phosphorylation of the growth and metastasis suppressor, N-myc down-stream regulated gene 1 (NDRG1) and the cdk inhibitpr p21CIP1/WAF. DpC completely blocked PANC-1 tumor growth in mouse xenografts.

DpC is an iron-chelating agent.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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