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SML0509 Sigma-Aldrich

JK-P3

≥98% (HPLC)

Synonym: 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, J,
InChI Key   QAZJUVDICQNITG-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

JK-P3 is a VEGFR-2 inhibitor.

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

FGFR

Fibroblast growth factors (FGFs) comprise a large family of signaling polypeptides. In the adult organism, FGFs are homeostatic factors and function in tissue repair and response to injury. In the em...
Keywords: Atomic absorption spectroscopy, Cancer, Cell proliferation, Diffusion, Diseases, Growth factors, Ligands, Nucleic acid denaturation, Phosphorylations, Sulfations, Transduction

VEGFR

The vascular endothelial growth factor receptor (VEGFR) family comprises in humans three endothelial cell (EC) specific tyrosine kinase receptors (VEGFR-1, VEGFR-2 and VEGFR-3). VEGFRs are the major ...
Keywords: Angiogenesis, Atomic absorption spectroscopy, Capillary electrophoresis, Cardiovascular, Growth factors, Ligands, Phosphorylations

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