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SML0511 Sigma-Aldrich

GNF-5

≥98% (HPLC)

Synonym: N-(2-Hydroxyethyl)-3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,
InChI Key   IIQUYGWWHIHOCF-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL (clear solution)
storage temp.   2-8°C

Description

Other Notes

GNF-5 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GNF-5 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

GNF-5 is a BRC-Abl inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Abl

The Abl family of non-receptor linked tyrosine kinases relay signals from diverse stimuli to promote changes in cell morphogenesis, migration, adhesion, proliferation and survival. Two Abl family kin...
Keywords: Adhesion, Atomic absorption spectroscopy, Catalysis, Central Nervous System, Genetic, Growth factors, Ligands, Microreactor technology, Morphogenesis, Phosphorylations, Rearrangements, Transcription

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

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