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SML0537 Sigma-Aldrich

MI-1

≥98% (HPLC)

Synonym: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-5,6,7,8-tetrahydro-[1]benzothieno[2,3-d]pyrimidine, CCG21397

  • CAS Number 433311-07-0

  • Empirical Formula (Hill Notation) C19H25N5S2

  • Molecular Weight 387.57

  •  MDL number MFCD03268791

  •  PubChem Substance ID 329825540

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 15 mg/mL (clear solution, warmed)
storage temp.   2-8°C
SMILES string   CC1(C)CN=C(S1)N2CCN(CC2)c3ncnc4sc5CCCCc5c34
InChI   1S/C19H25N5S2/c1-19(2)11-20-18(26-19)24-9-7-23(8-10-24)16-15-13-5-3-4-6-14(13)25-17(15)22-12-21-16/h12H,3-11H2,1-2H3
InChI key   MNSXQGKLDTVOLP-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MI-1 is a Menin-MLL interaction inhibitor. The mixed lineage leukemia (MLL) gene encodes MLL, a histone methyltransferase important in regulating gene transcription. MLL rearrangements and formation of fusion oncoproteins can block hematopoietic differentiation and increase proliferation, resulting in acute leukemias. Menin, encoded by the MEN1 gene, is a tumor suppressor associated with multiple endocrine neoplasia type 1. It also acts as an oncogenic co-factor of MLL fusion proteins. MI-1 inhibits Menin-MLL interaction with an IC50 of 1.9 micromolar.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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