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SML0560 Sigma-Aldrich

BRACO19 hydrochloride

≥96% (HPLC)

Synonym: N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride

  • Empirical Formula (Hill Notation) C35H43N7O2 · xHCl

  • Molecular Weight 593.76 (free base basis)

  •  MDL number MFCD23380200

  •  PubChem Substance ID 329825553

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Properties

Related Categories Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   MJAPNWJRLLDPAB-UHFFFAOYSA-N
assay   ≥96% (HPLC)
form   powder
color   yellow to brown
solubility   H2O: 5 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

BRACO19 hydrochloride has been used to study the role of antiviral activity of G4-stabilizing agents in cells infected with latent human immunodeficiency virus -1 (HIV-1).

Biochem/physiol Actions

BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Telomerase is associated with tumor progression and is highly expressed in a number of tumors. BRACO19 is known to prevent the capping and catalytic action of telomerase and thus, might serve as an effective therapeutic approach for cancer treatment. BRACO19 establishes antiviral activity against HIV (human immunodeficiency virus).

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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