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SML0570 Sigma-Aldrich

21H7

≥98% (HPLC)

Synonym: 6-Bromo-2-methyl-4-quinolinecarboxylic acid 2-[(2-hydroxyphenyl)methylene]hydrazide;

  • CAS Number 217317-45-8

  • Empirical Formula (Hill Notation) C18H14BrN3O2

  • Molecular Weight 384.23

  •  PubChem Substance ID 329825560

  •  NACRES NA.77

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Properties

Related Categories 0-9, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   Cc1cc(C(=O)NN=Cc2ccccc2O)c3cc(Br)ccc3n1
InChI   1S/C18H14BrN3O2/c1-11-8-15(14-9-13(19)6-7-16(14)21-11)18(24)22-20-10-12-4-2-3-5-17(12)23/h2-10,23H,1H3,(H,22,24)
InChI key   MTVVJOBPGQXHML-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

21H7 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. 21H7 decrease the viability of mouse B-lymphoma W10 cells, with LD50 values of 0.4 to 1.0 μM, while is significantly less cytotoxic to normal cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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