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SML0574 Sigma-Aldrich

YM-298198 hydrochloride

≥98% (HPLC)

Synonym: 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

  • CAS Number 1216398-09-2

  • Empirical Formula (Hill Notation) C18H22N4OS · HCl

  • Molecular Weight 378.92

  •  MDL number MFCD08703122

  •  PubChem Substance ID 329825561

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 5 mg/mL, clear
storage temp.   2-8°C
SMILES string   Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C
InChI   1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
InChI key   WYTJVUVCSUWZTH-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Glutamate Receptors (G Protein Family)

The existence of G protein-coupled glutamate receptors (also called "€œmetabotropic" glutamate or mGlu's), belonging to the seven transmembrane spanning superfamily of receptors, was shown definitive...
Keywords: Atomic absorption spectroscopy, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Obesity, Parkinson Disease, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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