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SML0577 Sigma-Aldrich

Cucurbitacin E

≥95% (HPLC)

Synonym: α-Elaterin, α-Elaterine

  • CAS Number 18444-66-1

  • Empirical Formula (Hill Notation) C32H44O8

  • Molecular Weight 556.69

  •  NACRES NA.77

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Properties

Related Categories Actin Inhibitors and Probes, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D -60 to -75°, c = 0.7 (CDCl3)
color   white to beige
solubility   DMSO: 15 mg/mL, clear
storage temp.   −20°C
InChI   1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChI key   NDYMQXYDSVBNLL-MUYMLXPFSA-N

Description

Application

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
RC6305500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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