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SML0579 Sigma-Aldrich

EVP4593

≥98% (HPLC)

Synonym: 4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine, N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine, QNZ

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   IBAKVEUZKHOWNG-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: 15 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.

Features and Benefits

This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitive

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Calcium Channels

The voltage-gated calcium channels constitute one group of a superfamily of ion channels that also includes sodium and potassium channels and amongst which exists functional, sequence and topological...
Keywords: Cardiovascular, Clinical, Diabetes, Gene expression, Hormones, Ligands, Neurotransmitters

Cytokine Receptors (Interleukin-1 Receptor/TIR Family)

The interleukin-1/TIR family in animals comprises three subgroups of proteins; of these, two are type I integral membrane receptor proteins and the third is a group of intracellular proteins. All fam...
Keywords: Gene expression, Hormones, Inflammation, Ligands, Transduction

Cytokine Receptors (Tumor Necrosis Receptor Family)

The cytokines and receptors of the Tumor Necrosis Factor (TNF) superfamily serve as an intercellular communication network integrating cellular responses in vertebrates. TNF receptors activate signal...
Keywords: Angiogenesis, Anti-inflammatory agents, Apoptosis, Calcification, Cancer, Cell proliferation, Diseases, Gene expression, Growth factors, Inflammation, Ligands, Transcription, Transduction

Peer-Reviewed Papers
15

References

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