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SML0659 Sigma-Aldrich

LYG-202

≥98% (HPLC)

Synonym: 5-Hydroxy-8-methoxy-7-[4-(4-methyl-1-piperazinyl)butoxy]-2-phenyl-4H-1-benzopyran-4-one

  • CAS Number 1175077-25-4

  • Empirical Formula (Hill Notation) C25H30N2O5

  • Molecular Weight 438.52

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 2 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LYG-202 is a synthetic flavanoid that induces apoptosis in several cancer cell lines. LYG-202 induces G1/S phase cell cycle arrest and apoptosis in HCT116 cells by a mechanism that involves increases in p21(WAF1/Cip1) and Rb expression. In HepG2 cells, the compound LYG-202 potentiates the apoptotic effects of TNFα by inhibiting casein kinase 2 (CK2).

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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