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SML0678 Sigma-Aldrich

Pyridostatin trifluoroacetate salt

≥98% (HPLC)

Synonym: 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt, RR82 trifluoroacetate salt

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
InChI Key   SLFYRKZWSPFGQZ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   white to beige
solubility   H2O: 15 mg/mL, clear
storage temp.   −20°C

Description

Application

Pyridostatin trifluoroacetate salt has been used as a G-quadruplex (G4) stabilizer to study interactions between RNA G4 and ligand molecules.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pyridostatin is a highly selective G-quadruplex interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage.

Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Light sensitive

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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