EMAIL THIS PAGE TO A FRIEND
SML0709 Sigma-Aldrich

GSK-J1

≥98% (HPLC)

Synonym: 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid; N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-Alanine

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
InChI Key   AVZCPICCWKMZDT-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 15 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

GSK-J1 has been used in formaldehyde dehydrogenase (FDH)-coupled demethylase assay.

Biochem/physiol Actions

GSK-J1 is a potent selective jumonji H3K27 demethylase inhibitor. Jumonji C domain-containing histone demethylases (JHDMs) are Fe(II) and α-ketoglutarate dependent enzymes that oxygenate methylated histone lysine residues and thereby cause their demethylation. GSK-J1 is selective for the KDM6 subfamily members JMJD3 and UTX with an IC50 of 60 nM in a JMJD3 assay, and is inactive against other demethylases of the JMJ family and over 100 tested kinases and histone deacetylases. For full characterization details, please visit the GSK-J1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.

Features and Benefits

GSK-J1 is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Comments

Add to Cart

SML1279 LLY-507, ≥97% (HPLC)
SML1276 BAZ2-ICR, ≥98% (HPLC)
PZ0307 PFI-4, ≥98% (HPLC)
SML1408 (R)-PFI-2, ≥97% (HPLC) SGC epigenetic chemical probe
SML1410 A-366, ≥98% (HPLC)
SML1486 NI-57, ≥98% (HPLC)
PZ0312 (S)-PFI-2 SGC epigenetic chemical probe
SML1534 I-BRD9, ≥98% (HPLC)
U4885 UNC0638 hydrate, ≥98% (HPLC) SGC epigenetic chemical probe
SML0067 IOX1, ≥97% (HPLC) SGC epigenetic chemical probe
SML0352 PFI-1, ≥98% (HPLC) SGC epigenetic chemical probe
SML0652 IOX2, ≥98% (HPLC) SGC epigenetic chemical probe
SML0662 UNC1215, ≥98% (HPLC)
SML0701 GSK-J4, ≥98% (HPLC) SGC epigenetic chemical probe
SML0768 GSK2801, ≥98% (HPLC) SGC epigenetic chemical probe
SML0766 GSK343, ≥98% (HPLC)
SML0778 UNC1999, ≥98% (HPLC)
SML0974 (+/-)-JQ1, ≥98% (HPLC) SGC epigenetic chemical probe
SML0992 Bromosporine, ≥98% (HPLC) SGC epigenetic chemical probe
SML0939 PFI-3, ≥98% (HPLC) SGC epigenetic chemical probe
SML1037 UNC0642, ≥98% (HPLC)
SML1072 GSK-LSD1, ≥98% (HPLC) SGC epigenetic chemical probe
SML1107 SGC0946, ≥98% (HPLC)
SML1133 SGC-CBP30, ≥98% (HPLC) SGC epigenetic chemical probe
SML1134 I-CBP112, ≥98% (HPLC) SGC epigenetic chemical probe
SML1184 OF-1, ≥98% (HPLC) SGC epigenetic chemical probe
SML1209 OICR-9429, ≥98% (HPLC)
SML1242 SGC707, ≥98% (HPLC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?