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SML0721 Sigma-Aldrich

LSN2463359

≥98% (HPLC)

Synonym: N-(1-Methylethyl)-5-(pridin-4-ylethynyl)pyridine-2-carboxamide

  • CAS Number 1401031-52-4

  • Empirical Formula (Hill Notation) C16H15N3O

  • Molecular Weight 265.31

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 10 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LSN2463359 is a selactive brain penetrant mGluR5 positive allosteric modulator. LSN2463359 is a potentiator of mGluR5-mediated Ca2+ influx in vitro, giving curve shifts 2 to 3 fold over agonist alone. In vivo, the compound exerts wake-promoting, cognitive and motor effects.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

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Protocols & Articles

Articles

Glutamate Receptors (G Protein Family)

The existence of G protein-coupled glutamate receptors (also called "€œmetabotropic" glutamate or mGlu's), belonging to the seven transmembrane spanning superfamily of receptors, was shown definitive...
Keywords: Atomic absorption spectroscopy, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Obesity, Parkinson Disease, Schizophrenia, Transduction

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