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SML0726 Sigma-Aldrich

Panepoxydone

from Lentinus conatus, ≥95% (HPLC)

Synonym: (1S,5R,6S)-5-Hydroxy-3-[(1S)-1-hydroxy-3-methyl-2-buten-1-yl]-7-oxabicyclo[4.1.0]hept-3-en-2-one

  • CAS Number 31298-54-1

  • Empirical Formula (Hill Notation) C11H14O4

  • Molecular Weight 210.23

  •  NACRES NA.77

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
Quality Level   200
biological source   Lentinus conatus
assay   ≥95% (HPLC)
form   powder
storage condition   protect from light
solubility   DMSO: soluble 10 mg/mL
storage temp.   −20°C
InChI   1S/C11H14O4/c1-5(2)3-7(12)6-4-8(13)10-11(15-10)9(6)14/h3-4,7-8,10-13H,1-2H3/t7?,8-,10+,11-/m1/s1
InChI key   MBXKEYXHJAZKBP-VQZXEUHYSA-N

Description

Biochem/physiol Actions

Panepoxydone is a fungal metabolite that inhibits NF-κB transcription factor by preventing IκB phosphorylation, thus inhibiting the release of NF-κB from the IκB : NF-κB complex and its translocation into the nucleus. Panepoxydone also has antimalarial, cytotoxic activities and anti-parasitic activity against Trypanosoma cruzi.

Reconstitution

Soluble in ethyl acetate, ethanol, and DMSO (10mg/ml). The product is soluble, but not stable in water and methanol.

Other Notes

Store the product sealed at -20 °C, protect from light. Under these conditions, the product is stable for at least 2 years.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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