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SML0762 Sigma-Aldrich

Enzastaurin

≥98% (HPLC)

Synonym: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione, D04014, LY-317615, LY317615

  • CAS Number 170364-57-5

  • Empirical Formula (Hill Notation) C32H29N5O2

  • Molecular Weight 515.60

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, E,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   , light orange to dark orange-red
solubility   DMSO: 10 mg/mL, clear (warmed)
storage temp.   −20°C

Description

Application

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.

It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

Features and Benefits

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GSK-3

GSK-3 is a highly conserved family of protein kinases. In humans, two genes encode two distinct, but closely related GSK-3 forms, referred to as GSK-3α and GSK-3β. They display 84% overall identity a...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, Cell division, Diabetes, Diseases, Huntington Disease, Ligands, Neurodegenerative Diseases, Parkinson Disease, Phosphorylations, Schizophrenia, Transcription, Transduction

PKB/Akt

The PDK1–PKB/Akt axis represents one of the most actively researched cell signaling pathways. This protein kinase cascade is known to play a central role in mediating the actions of a range of stimul...
Keywords: Apoptosis, Atomic absorption spectroscopy, Cancer, Cell proliferation, Cell signaling, Diabetes, Gene expression, Growth factors, Inflammation, Metabolism, Myristoylations, Phosphorylations, Reversible addition-fragmentation chain transfer polymerizations

Peer-Reviewed Papers
15

References

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