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SML0776 Sigma-Aldrich

Galloflavin

≥95% (HPLC)

Synonym: 3,8,9,10-Tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione, NSC 107022

  • CAS Number 568-80-9

  • Empirical Formula (Hill Notation) C12H5O8

  • Molecular Weight 277.16

  •  MDL number MFCD26941292

  •  PubChem Substance ID 329825597

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, G
InChI Key   VYKVZHXHVUVABA-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   light yellow to light brown
solubility   DMSO: 5 mg/mL, clear
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Galloflavin is an inhibitor of lactate dehydrogenase (LDH). The compound blocks both isoforms of (LDH-A and –B) with Ki values of 5.5 and 15 μM, respectively. Inhibition of the glycolytic pathway by galloflavin induces oxidative stress and apoptosis in breast tumor cell lines.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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