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SML0798 Sigma-Aldrich

Osanetant

≥98% (HPLC)

Synonym: (R)-N-{{3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl}-4-phenylpiperidin-4-yl}-N-methylacetamine, SR-142801, SR142801

  • CAS Number 160492-56-8

  • Empirical Formula (Hill Notation) C35H41Cl2N3O2

  • Molecular Weight 606.62

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +18 to +24°, c = 1 in methanol
color   white to beige
solubility   DMSO: 15 mg/mL, clear
storage temp.   −20°C
InChI   1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1
InChI key   DZOJBGLFWINFBF-UMSFTDKQSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Osanetant is a selective antagonist of neurokinin 3 receptor NK3. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Osanetant was in clinical trials for both irritable bowel syndrome and schizophrenia.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Tachykinin Receptors

The tachykinins represent a large family of peptides whose common structural feature is the C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2. Substance P (SP), neurokinin A (NKA), neurokinin B (N...
Keywords: Atomic absorption spectroscopy, Clinical, Diseases, Gastrointestinal, Gene expression, Inflammation, Neurotransmission, Schizophrenia, Transduction

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