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SML0873 Sigma-Aldrich

Y16

≥98% (HPLC)

Synonym: 4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione

  • CAS Number 429653-73-6

  • Empirical Formula (Hill Notation) C24H20N2O3

  • Molecular Weight 384.43

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Y
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   , faint yellow to dark orange
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways. Y16 blocks the growth and migration of MCF7 breast cancer cells.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Product is a racemic mixture of E/Z isomers.

Safety & Documentation

Safety Information

RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

GTP Binding Proteins (Low Molecular Weight)

The approximately 150 members of the human Ras superfamily of low molecular weight GTP binding proteins function as regulators of diverse cellular processes. Most Ras superfamily members have intrins...
Keywords: Absorption, Acetylations, Atomic absorption spectroscopy, Cancer, Cellular processes, Diseases, Enzyme activity, Farnesylations, Geranylgeranylations, Myristoylations, Palmitoylations, Post translational modifications, Rearrangements, Transduction

Peer-Reviewed Papers
15

References

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