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SML0880 Sigma-Aldrich

Shz-1

≥98% (HPLC)

Synonym: 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide benzenesulfonic acid

  • CAS Number 326886-05-9

  • Empirical Formula (Hill Notation) C13H11BrN2O3S

  • Molecular Weight 355.21

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL, clear
storage temp.   −20°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Shz-1 is an enhancer of myocardial regenerative repair by stem cells. Shz-1 specifically activates Nkx2.5, one of the earliest lineage-restricted genes to be expressed in cardiovascular progenitor cells and improves iPSC-derived cardiac differentiation. Shz-pretreated human mobilized peripheral blood mononuclear cells (PBMCs) injected in a rodent model of myocardial infarction enhanced engraftment of the cells and improved cardiac function.

The members of sulfonyl-hydrazone family are known to induce differentiation in cardiomyocytes.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

Peer-Reviewed Papers
15

References

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