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SML0920 Sigma-Aldrich

α-Phenyl tropolone

≥98% (HPLC)

Synonym: 2-Hydroxy-3-phenyl-2,4,6-cycloheptatrien-1-one, 3-Phenyltropolone

  • CAS Number 341033-14-5

  • Empirical Formula (Hill Notation) C13H10O2

  • Molecular Weight 198.22

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   , yellow to gray to brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8 (Ki = 0.26 and 1.09 nM, respectively). The compound, α-Phenyl tropolone, does not affect other HDAC isoforms up to concentrations of 20 μM, with the exception of HDAC 6 (Ki = 527 nM).

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

Peer-Reviewed Papers
15

References

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