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SML1054 Sigma-Aldrich

SBI-0087702

≥98% (HPLC)

Synonym: 4-Methoxy-N-[2-(4-methoxyphenyl)ethyl]-1-naphthalenemethanamine

  • CAS Number 864431-36-7

  • Empirical Formula (Hill Notation) C21H23NO2

  • Molecular Weight 321.41

  •  MDL number MFCD01135860

  •  PubChem Substance ID 329825640

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
assay   ≥98% (HPLC)
form   powder
color   white to light brown
solubility   DMSO: 5 mg/mL, clear (warmed)
storage temp.   room temp
SMILES string   COC1=C2C(C=CC=C2)=C(CNCCC3=CC=C(OC)C=C3)C=C1
InChI   1S/C21H23NO2/c1-23-18-10-7-16(8-11-18)13-14-22-15-17-9-12-21(24-2)20-6-4-3-5-19(17)20/h3-12,22H,13-15H2,1-2H3
InChI key   SNBZXHDTILHVJS-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SBI-0087702 promotes the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

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