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SML1083 Sigma-Aldrich

Ethacrynic acid

≥97% (HPLC)

Synonym: (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid, 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, ECA, Etacrynic acid, [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid

  • CAS Number 58-54-8

  • Empirical Formula (Hill Notation) C13H12Cl2O4

  • Molecular Weight 303.14

  •  EC Number 200-384-1

  •  MDL number MFCD00056693

  •  PubChem Substance ID 329825461

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
assay   ≥97% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
InChI   1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChI key   AVOLMBLBETYQHX-UHFFFAOYSA-N
Gene Information   human ... SLC12A1(6557)

Description

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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