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SML1089 Sigma-Aldrich

AZ191

≥98% (HPLC)

Synonym: [2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   , white to yellow to light brown
solubility   DMSO: 10 mg/mL, clear
storage temp.   −20°C
SMILES string   CN1C2=CN=CC=C2C(C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3)=C1
InChI   1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChI key   ZYVXTMKTGDARKR-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B that promotes a G1 cell cycle arrest.

Other Notes

AZ191 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the AZ191 probe summary on the Chemical Probes Portal website.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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