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SML1097 Sigma-Aldrich

BC8-15

≥98% (HPLC)

Synonym: 3-[(3-Ethyl-1,2,4-triazolo[4,3-c]quinazolin-5-yl)amino]-benzoic acid

  • CAS Number 950385-77-0

  • Empirical Formula (Hill Notation) C18H15N5O2

  • Molecular Weight 333.34

  •  PubChem Substance ID 329825474

  •  NACRES NA.77

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   CCC1=NN=C2N1C(NC3=CC=CC(C(O)=O)=C3)=NC4=CC=CC=C42
InChI   1S/C18H15N5O2/c1-2-15-21-22-16-13-8-3-4-9-14(13)20-18(23(15)16)19-12-7-5-6-11(10-12)17(24)25/h3-10H,2H2,1H3,(H,19,20)(H,24,25)
InChI key   INDKHRIZOIEPIG-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BC8-15 has the ability to block PDE8A (phosphodiesterase 8A) and PDE4A (phosphodiesterase 4A) with IC50 values of 280 and 220 nM. It helps to increase the synthesis of the steroid from both primary Leydig cells and MA-10 cells.

BC8-15 is a potent PDE4/8 inhibitor that elevates steroidogenesis in mouse Leydig cells.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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