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SML1115 Sigma-Aldrich

CP466722

≥98% (HPLC)

Synonym: 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-Triazol-5-amine

  • CAS Number 1080622-86-1

  • Empirical Formula (Hill Notation) C17H15N7O2

  • Molecular Weight 349.35

  •  MDL number MFCD17392566

  •  PubChem Substance ID 329825656

  •  NACRES NA.77

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Properties

Related Categories ATM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 0.5 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   NC1=NC(C2=CC=CC=N2)=NN1C3=NC=NC4=C3C=C(OC)C(OC)=C4
InChI   1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23)
InChI key   ILBRKJBKDGCSCB-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase. The compound CP466722 disrupts ATM-dependent checkpoint cell cylce events, and reverses ATM-dependent substrate phosphorylation and downstream signaling events following exposure to ionizing radiation.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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