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SML1158 Sigma-Aldrich

(2S)-Hypusine dihydrochloride

≥95% (HPLC)

Synonym: (+)-Hypusine dihydrochloride, N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride

  • Empirical Formula (Hill Notation) C10H23N3O3 · 2HCl

  • Molecular Weight 306.23

  •  PubChem Substance ID 329825688

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 15 mg/mL, clear
storage temp.   −20°C
SMILES string   [H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
InChI   1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
InChI key   UTSZZUVUESAPQD-AHBBCRTASA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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