• USA Home
  • SML1160 - CD40-TRAF6 signaling inhibitor

EMAIL THIS PAGE TO A FRIEND
SML1160 Sigma-Aldrich

CD40-TRAF6 signaling inhibitor

≥98% (HPLC)

Synonym: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one, Compound 6877002

  • CAS Number 433249-94-6

  • Empirical Formula (Hill Notation) C17H17NO

  • Molecular Weight 251.32

  •  PubChem Substance ID 329825690

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
InChI   1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI key   WIFPLULEUNBSTE-GZTJUZNOSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.

CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?