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SML1176 Sigma-Aldrich

Carboxypyridostatin trifluoroacetate salt

≥95% (HPLC)

Synonym: 4-[[[2,6-Bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-1H-1,2,3-triazole-1-propanoic acid trifluoroacetate salt, carboxyPDS trifluoroacetate salt

  • CAS Number 1417638-60-8 (free base)

  • Empirical Formula (Hill Notation) C35H34N10O7 · xC2HF3O2

  • Molecular Weight 706.71 (free base basis)

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to light brown
solubility   H2O: 25 mg/mL, clear
storage temp.   −20°C

Description

Other Notes

Light sensitive

Packaging

5, 25 mg in glass bottle

Application

Carboxypyridostatin trifluoroacetate salt has been used in the study of translation, stimulated by DHX36 (DEAH-box helicase 36) binding at G-rich sites in mRNA untranslated regions.

Biochem/physiol Actions

Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures. Immunofluorescent staining of carboxyPDS treated cells using an anti G-quadruplex antibody reveals staining only in the cytoplasm and not the nucleus, demonstrating selectivity against DNA G-quadruplex structures.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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