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SML1230 Sigma-Aldrich

XW4.4

≥98% (HPLC)

Synonym: 5-(2,6-Dichlorophenylsulfonamido)-N-(4-fluorobenzyl)-1H-pyrrole-2-carboxamide, 5-[[(2,6-Dichlorophenyl)sulfonyl]amino]-N-[(4-fluorophenyl)methyl]-1H-pyrrole-2-carboxamide

  • CAS Number 1244957-89-8

  • Empirical Formula (Hill Notation) C18H14Cl2FN3O3S

  • Molecular Weight 442.29

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

XW4.4 can generate insulin-producing cells from rat mesenchymal stem cells. XW4.4 induced pancreatic differentiation of rat bone marrow derived mesenchymal stem cells into insulin-producing cells shown to release C-peptide and insulin in response to physiological or high glucose levels, which could lead to a possible treatment for Type 1 diabetes. Its mechanism of action is postulated to be through increasing expression of hepatocyte nuclear factor 3β (HNF3β), a member of the forkhead box transcription factor family that regulates expression of several genes in the pancreas during early embryogenesis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
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