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SML1234 Sigma-Aldrich

HAMNO

≥98% (HPLC)

Synonym: (1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847

  • CAS Number 138736-73-9

  • Empirical Formula (Hill Notation) C17H13NO2

  • Molecular Weight 263.29

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 10 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


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Protocols & Articles
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