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SML1277 Sigma-Aldrich

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

Synonym: Geldanamycin, fluorescein isothiocyanate labeled

  • Empirical Formula (Hill Notation) C55H63N5O13S

  • Molecular Weight 1034.18

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antibiotics by Mechanism of Action,
biological source   Streptomyces hygroscopicus
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   yellow to yellow-orange
solubility   DMSO: soluble 5 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
storage temp.   −20°C

Description

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

General description

Chemical structure: benzenoid

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


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Protocols & Articles
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