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SML1278 Sigma-Aldrich

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

Synonym: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)

  • CAS Number 30562-34-6

  • Empirical Formula (Hill Notation) C29H40N2O9

  • Molecular Weight 560.64

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Description

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

General description

Chemical structure: benzenoid

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18
Keywords: Antibiotics, Chromatography, Clinical, High performance liquid chromatography, Separation, Solvents

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