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SML1281 Sigma-Aldrich

Capecitabine Ready Made Solution

10 mg/mL in DMSO

Synonym: 5′-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

  • CAS Number 154361-50-9

  • Empirical Formula (Hill Notation) C15H22FN3O6

  • Molecular Weight 359.35

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, DNA Synthesis Inhibitors, DNA metabolism,
Quality Level   200
form   DMSO solution
concentration   10 mg/mL in DMSO
shipped in   dry ice
storage temp.   −20°C
InChI   1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
InChI key   GAGWJHPBXLXJQN-UORFTKCHSA-N

Description

Biochem/physiol Actions

Capecitabine is a fluoropyrimidine carbamate that undergoes preferential conversion to 5-fluorouracil in cancerous tissues.

Capecitabine is an anti-cancer drug, a prodrug of doxifluridine, metabolized to 5-fluorouracil at the tumor site. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5′-Deoxy-5-fluorocytidine (5′-DFCR) and 5′-Deoxy-5-fluorouridine (5′-DFUR), to form 5-fluorouracil.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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