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SML1342 Sigma-Aldrich

API-1

Synonym: 4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide, NSC 177223, NSC177223

  • CAS Number 36707-00-3

  • Empirical Formula (Hill Notation) C13H15N5O6

  • Molecular Weight 337.29

  •  MDL number MFCD18086904

  •  PubChem Substance ID 329825799

  •  NACRES NA.77

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥95% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 1 mg/mL, clear (warmed)
storage temp.   −20°C
SMILES string   O=C1C(C(N)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3
InChI   1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
InChI key   SPBWHPXCWJLQRU-FITJORAGSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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