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SML1344 Sigma-Aldrich

AK-1

≥98% (HPLC)

Synonym: 3-[(Hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide

  • CAS Number 330461-64-8

  • Empirical Formula (Hill Notation) C19H21N3O5S

  • Molecular Weight 403.45

  •  MDL number MFCD01122550

  •  PubChem Substance ID 329825801

  •  NACRES NA.77

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 20 mg/mL, clear
storage temp.   −20°C
SMILES string   O=S(N1CCCCCC1)(C2=CC(C(NC3=CC=CC([N+]([O-])=O)=C3)=O)=CC=C2)=O
InChI   1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23)
InChI key   HAYBKCHPEBZNGW-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

AK-1 is a benzylsulfonamide. It acts as avia inhibiting of the nuclear factor-KB (NF-KB) /CSN2 (casein β) pathway.

AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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