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SML1353 Sigma-Aldrich

ML351

≥98% (HPLC)

Synonym: 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile, CID 664510, ML 351, SID 104223766

  • CAS Number 847163-28-4

  • Empirical Formula (Hill Notation) C15H11N3O

  • Molecular Weight 249.27

  •  MDL number MFCD04183120

  •  PubChem Substance ID 329825808

  •  NACRES NA.77

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Properties

Related Categories Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL, clear
storage temp.   2-8°C
SMILES string   CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2
InChI   1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3
InChI key   DYXYXTDIFMDJIR-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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