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SML1368 Sigma-Aldrich

CLP257

≥98% (HPLC)

Synonym: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

  • CAS Number 1181081-71-9

  • Empirical Formula (Hill Notation) C14H14FN3O2S

  • Molecular Weight 307.34

  •  MDL number MFCD28166488

  •  PubChem Substance ID 329825822

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   , white to yellow to light brown
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
InChI   1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChI key   SKCADXVKQRCWTR-GHXNOFRVSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CLP257 is a selective K+-Cl cotransporter KCC2 activator that restored impaired Cl transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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