• USA Home
  • SML1412 - KRIBB11 trifluoroacetate salt

EMAIL THIS PAGE TO A FRIEND
SML1412 Sigma-Aldrich

KRIBB11 trifluoroacetate salt

≥98% (HPLC)

Synonym: 2,6-Pyridinediamine trifluoroacetate salt, N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine trifluoroacetate salt, N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine trifluoroacetate salt

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
InChI Key   DNBQMABUWGNHGB-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

KRIBB11 is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?