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SML1447 Sigma-Aldrich

Clemizole hydrochloride

≥98% (HPLC)

Synonym: 1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride, 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride, 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride, CID 2782 hydrochloride, NSC 46261 hydrochloride

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Properties

Related Categories Antagonists- Histaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Calcium Channel Modulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 2 mg/mL, clear (warmed)
storage temp.   2-8°C
SMILES string   ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
InChI   1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChI key   DNFMJYXRIMLMBZ-UHFFFAOYSA-N

Description

General description

Clemizole is a potent anti-allergic drug.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.

Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
DD6730000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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